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Haptoglobin and free hemoglobin

Combined into a composite, showing a new antigenic determinants, the mononuclear cells, the hemoglobin of the surface of the macrophage Clear recognizes and binds receptor (CD163), after being swallowed degradation to the removed blood circulation free hemoglobin. This physiological phenomenon, a very interesting reference for clinical laboratory science indicators. When doctors experimental instrument found that the serum binding globin decreased, combined with the patient's clinical manifestations, can determine whether an intravascular hemolytic disease, such as paroxysmal nocturnal hemoglobinuria and favism, and congenital absence beads albumin. There are some other types of intravascular hemolysis and extravascular hemolysis haptoglobin can be reduced, the degree of reduction in regular and the severity of the disease of the same.